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| EVIDENCE FOR EFFICACY (HUMAN DATA) |
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| Clinical Trials |
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Aloe vera gel is statistically significantly more effective than placebo in inducing clinical and symptomatological improvement of oral lichen planus in 54 consecutive patients.
Choonhakarn 2008
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Study found that use of complementary and alternative medicine with the most common types being homeopathy, vitamins and minerals, modified diet, aloe vera & cinnamon in children with type 1 diabetes is less common than that documented for adults.
Dannemann 2008
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A statistically significant improvement in healing occurred for wounds cleansed with saline spray containing Aloe vera, silver chloride and decyl glucoside compared with isotonic saline.
Moore 2008
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The anti-inflammatory potential of a highly concentrated Aloe vera gel in the UV erythema test in vivo was explored and its usefulness was confirmed against UV-induced Erythema in a randomized, double-blind, placebo-controlled, phase III monocenter study.
Reuter 2008
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An anionic polar phospholipid-(APP) based cream and an aloe vera-based gel were compared to determine their effectiveness in preventing and treating radiation dermatitis in 45 pediatric patients revealing that APP cream is more effective.
Merchant 2007
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A non-blinded three armed study of the effect of Aloe vera, Essex and no lotion on erythema, which is an effect of radiotherapy treatment in breast cancer patients was performed with 50 women and showed no significant median differences between the pairs of different treatments.
Nystr?007
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Among the pediatric otolaryngology patients, the commonly used complementary and alternative medicine preparations were cod-liver oil, echinacea, aloe vera, cranberry, primrose oil and herbal vitamin supplements.
Shakeel 2007
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Of the 33 interventions including aloe vera, antibiotic pastille or paste in the trial, 12 showed some evidence of a benefit for either preventing or reducing the severity of mucositis associated with cancer treatment.
Worthington 2007
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Previous history of polycystic ovarian syndrome, number of prior treatments, use of aloe vera cooling gel, and sex of patient had no apparent effect on the incidence of acneform lesions and the acneform reactions are relatively common after laser hair removal.
Carter 2006
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The effect of cosmetic formulations of freeze-dried Aloe vera extract on skin hydration, after a single and a 1 to 2-week period of application in volar forearm of 20 females, by using skin bio-engineering techniques showed improvement in skin hydration, by a humectant mechanism.
Dal'Belo 2006
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Assessment of the efficacy of Aloe vera (AV) on irritable bowel syndrome (IBS) in refractory secondary care patients indicated that there was no evidence that AV benefits patients with IBS.
Davis 2006
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The amount of citrate & tartrate in aloe gel, & in the urine of healthy normal children, before & after consuming fresh aloe gel found that changes in chemical composition of urine after aloe gel consumption show potential for preventing kidney stone formation in children.
Kirdpon 2006
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Incorporation of sunscreening agent-loaded microspheres into aloe vera gel greatly increased the efficacy of sunscreen formulation more than 4 times when evaluated for skin irritation test in human volunteers, and sun protection factor and minimum erythema dose in albino rats.
Patel 2006
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Study of interventions for preventing oral mucositis for patients with cancer receiving treatment shows that, of the 29 interventions including Aloe vera & camomile in the trials, 10 showed some evidence of benefit for either preventing or reducing severity of mucositis.
Worthington 2006
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The effect of the commercial Aloe vera gel in 41 patients with stable plaque psoriasis was modest and not better than placebo.
Paulsen 2005
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Study on 20 volunteers showed that aloe vera cream has no sunburn or suntan protection and no efficacy in sunburn treatment when compared to placebo. The aloe vera cream has no bleaching effect either.
Puvabanditsin 2005
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A double-blind, randomized, placebo-controlled trial of the efficacy and safety of aloe vera gel for treatment of mild to moderately active ulcerative colitis was performed in 44 out-patients and showed that oral aloe vera taken for 4 weeks produced a clinical response more often than placebo.
Langmead 2004
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In a randomized study with 58 head-and-neck cancer patients, oral aloe vera was not a beneficial adjunct to head-and-neck radiotherapy.
Su 2004
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While a single small trial of aloe vera supplementation vs gauze suggests delayed healing with aloe vera, the results of this trial are uninterpretable since there was a large differential loss to follow up.
Vermeulen 2004
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[A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention and treatment of radiation dermatitis].
Bosley 2003
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Gradual delivery of AV gel to skin by dry-coated Aloe vera gloves produced improved skin integrity, decreased appearance of fine wrinkling, and decreased erythema in occupational dry skin and irritant contact dermatitis.
West 2003
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Aloe vera gel did not significantly reduce radiation-induced skin side effects of breast cancer patients where as aqueous cream was useful in reducing dry desquamation and pain related to radiation therapy
Heggie 2002
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Acemannan Hydrogel Patch significantly reduced the incidence of alveolar osteitis in molar extraction sites compared with clindamycin-soaked Gelfoam.
Poor 2002
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The clinical effects of saline and Aloe vera rinses on periodontal surgical sites. (No abstract)
Rieger 2002
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A clinical trial on whether use of mild soap alone or mild soap + Aloe vera gel would decrease incidence of skin reactions in patients undergoing radiation therapy revealed a protective effect of adding Aloe to the soap regimen only when the cumulative dose increases over time.
Olsen 2001
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Clear benefit could not be established of a gel containing silicon dioxide, aloe
vera, and allantoin for healing of recurrent oral aphthous ulcers in a
randomized 3-4-month trial
Garnick 1998
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Cancer progression was slowed when A. vera tincture (1 ml twice/day) was
added to melatonin (20 mg/day orally) than by melatonin alone in a small trial with 50 cancer patients
Lissoni 1998
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Carrasyn, a hydrogel from aloe approved by the FDA for pressure ulcers, gave no advantage over a moist saline gauze dressing in a randomized trial with 30
patients for 10 weeks
Thomas 1998
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Among cancer patients, radiation therapy-induced dermatitis was not reduced among those getting aloe gel
Williams 1996
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The decline of CD4 in HIV patients was not prevented by acemannan @ 1600
mg/d orally
Montaner 1996
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Slight to moderate chronic plaque-type psoriasis was cured in 4 weeks with 0.5% Aloe extract in 25/30 patients (83.3%) compared to the placebo cure rate of 2/30 (6.6%) and clearing of psoriatic plaques was 328/396 (82.8%) vs placebo 28/366 (7.7%)
Syed 1996
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Burns healed faster with aloe vera gel than vaseline gauze, 12 vs. 18 days in a trial with 27 patients
Visuthikosol 1995
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In a double-blind trial, a combination of celandin, aloe vera and psyllium, showed increased bowel movements, soft stools and less laxative dependence compared to placebo.
Odes 1991
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From 21 women with healing complications after gynecologic surgery, those treated with aloe vera gel required 83 days and those on standard treatment healed in 53 days
Schmidt 1991
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5000 angina patients adding the 'Husk of Isabgol' and 'aloe vera' to their diet had reduced total serum cholesterol, serum triglycerides, fasting and post prandial blood sugar level in diabetic patients, total lipids and also increased HDL
Agarwal 1985
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Double-blind comparison of alophen with its components for cathartic effects. (No abstract)
Chapman 1974
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| Observational Studies/Case Reports |
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[Several cases of liver affected by aloe vera] [Article in Swedish]
Belfrage 2008
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A case of possible oral aloe vera-induced hepatitis was reported in 73-year-old female who used oral aloe vera capsules for constipation.
Bottenberg 2007
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A case of a 72-year-old woman observed for dermatitis on the legs followed by apperance of erythema on the eyelids was presented and she had a past history of peripheral venous insufficiency and had been using self home-made Aloe vera juice over the legs for relief from pain.
Ferreira 2007
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The study tracked effect of aloe-vera impregnated gloves on attitudes about hand hygiene among many health care workers and their perceived sense of skin condition.
Korniewicz 2007
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It is suggested that a combination of interferon and herbal therapy (aloe vera-propolis) with B complex is an effective, atraumatic and simple non-surgical treatment of human papillomavirus infection tested in women with different cervical lesions.
Iljazovi?006
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Fresh Aloe vera gel (100 g) contains 96.3 mg of citrate and 158.9 mg of tartrate. This is mid-range for Thai fruits. Changes in chemical compositions of urine after aloe consumption shows its potential for preventing kidney stone formation among adults.
Kirdpon 2006a
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There is limited controlled evidence indicating efficacy of traditional Chinese medicines, aloe vera gel, wheat grass juice, Boswellia serrata and bovine colostrum enemas in ulcerative colitis.
Langmead 2006
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It is suggested that APS-1, a polysaccharide from Aloe vera var. chinensis, could be of considerable preventive and therapeutic significance to some free radical associated health problems such as coronary heart ailments, Parkinson's and Alzheimer's diseases.
Wu 2006
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A case of Henoch-Schonlein purpura, a systemic vasculitis, in an adult patient who had previously received the herb Aloe vera was reported.
Evangelos 2005
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Review on novel approaches to radiotherapy-induced skin reactions suggests that using a hydrophilic substance such as Aloe vera gel or vegetable oil that is high in essential fatty acids, is as effective as mild steroid creams such as 1% hydrocortisone in reducing the severity of reactions.
Maddocks-Jennings 2005
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A statistically significant improvement in pressure ulcer healing for wounds cleansed with saline spray containing Aloe vera, silver chloride and decyl glucoside (Vulnopur) when compared with isotonic saline solution was noted.
Moore 2005
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Hepatitis in a 57-year old female could be linked to the ingestion of Aloe barbadensis miller compounds. The patient's hepatitis resolved completely after discontinuing this medication.
Rabe 2005
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There is no evidence from clinical trials to suggest that topical Aloe vera is effective in preventing or minimising radiation-induced skin reactions in cancer patients.
Richardson 2005
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Use of an aloe vera gel resulted in full healing after treatments such as antibiotics, surgical debridement and skin grafting had failed.
Avijgan 2004
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Review on prevention and treatment of acute radiation dermatitis indicates that Aloe vera may be beneficial and is not harmful.
Wickline 2004
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[Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure].
Mitchell 2003
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Review of a total of 108 trials examining 36 herbs and 9 vitamin/mineral supplements, involving 4,565 patients with diabetes revealed that these herbs are generally safe and plants like Aloe vera have positive preliminary results.
Yeh 2003
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Data on atopic dermatitis and chronic venous insufficiency treated with aloe Aloe vera gel and tea tree oil indicated that there is no compelling evidence for their effectiveness as reviewed from the various clinical studies.
Ernst 2002
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Including Aloe vera, 45 plants and their products (active, natural principles and crude extracts) that have been mentioned/used in the Indian traditional system of medicine have shown experimental or clinical evidence of anti-diabetic activity.
Grover 2002
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Beneficial aspects of medicinal plants on skin include: healing of wounds and burn injuries (especially Aloe vera)
Mantle 2001
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Surgeons should question patients about use of common herbal remedies, as some may increase the risk of bleeding, or photosensitivity reaction, and some may be beneficial for wound healing (aloe vera gel).
Pribitkin 2001
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A new bioadhesive patch of Aloe vera hydrogel, tried for aphthous stomatitis found effective in more than 80% of cases with 90% compliance in adhesivity, acceptability and palatability of the formulation. [Article in Italian]
Andriani 2000
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Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively for the prevention and treatment of peptic ulcer and their clinical efficacy documented.
Borrelli 2000
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The effects, clinical studies, side effects, and dosing regimens for aloe vera, arnica, black cohosh, evening primrose oil, and saw palmetto are reviewed.
Cohen 2000
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Studies on Aloe vera, and many other plants indicate that these plants may be of value in selected dermatological indications.
Grimme 1999
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A case of successful treatment of Lichen planus, a disease that involves the skin and mucous membranes, with Aloe vera is described.
Hayes 1999
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Review of Aloe has revealed the therapeutic claims in inflammation, immuno-modulatory properties, antidiabetic, anticancer and antibiotic activities
Reynolds 1999
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Review of authentic literature of Aloe vera based on controlled clinical trials revealed that, even though there are some promising results, clinical effectiveness of oral or topical aloe Aloe vera is not sufficiently defined at present.
Vogle 1999
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Encouraging results for topical and oral aloe treatment of chronic venous leg ulcers call for larger research studies
Atherton 1998
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Nutritional supplements such as aloe vera and other plant derived saccharides
appeared to help improve fibromyalgia and chronic fatigue syndrome in 50
patients followed 9 months
Dykman 1998
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Natural cancer therapy with pineal indole melatonin plus Aloe vera extracts may produce some therapeutic benefits, at least in terms of stabilization of disease and survival, in patients with advanced solid tumors.
Lissoni 1998
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A review which discusses many agents used in treating Inflammatory bowel disease including the aloe vera derivative acemannan.
Robinson 1998
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Review of non conventional topical therapies for wound care including aloe
vera, etc
Rund 1996
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Aloe may be used in domestic conditions for increasing the defensive forces of the body during radiation lesions. [Article in Ukrainian]
Iena IaM 1993
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Dermabrasion healing was faster in areas where aloe was added to
polyethylene oxide gel dressing
Fulton 1990
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In frostbite, application of Aloe vera cream combats the local vasoconstrictive effects of thromboxane.
McCauley 1990
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Combination of chemotherapy in cases of pulmonary tuberculosis using desensitizing agents and tissue preparations (a suspension of placenta tissue and aloe) had an immunomodulating effect. [Article in Russian]
Nersesian
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Aloe injection lowered sGPT levels by 86.8%. in 38 patients of chronic hepatitis with positive HBsAg. [Article in Chinese]
Fan 1989
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Studies and case reports provide support for the use of aloe vera in the treatment of radiation ulcers and stasis ulcers in humans.
Klein 1988
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Three patients with chronic osteoma cutis secondary to acne vulgaris were treated postoperatively, with Aloe-vera-soaked polyethylene oxide gel dressings with excellent cosmetic results.
Fulton 1987
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Dried sap of the Aloe plant was studied in 5 patients with non-insulin-dependent diabetes and in Swiss albino mice made diabetic using alloxan. Aloe contains a hypoglycaemic agent which lowers the blood glucose.
Ghannam 1986
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Modern clinical use of the mucilaginous gel from the parenchymatous cells in
the leaf pulp began in the 1930s, with reports of successful treatment of X-ray
and radium burns
Grindlay 1986
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"Aloe Vera in dentistry " (no abstract)
Sturm 1984
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Use of aloe in complex treatment of patients with focal pulmonary tuberculosis. [Article in Russian](No abstract)
Kurilenko 1974
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| Traditional and Folk Use |
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The data available in the literature for nine botanicals including Ginseng, Aloe Vera, that are frequently promoted to help manage blood glucose was reviewed.
Cefalu 2008
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The effects of different edible coatings including Aloe vera gel (1:1 v/v), A.vera gel(100%) on mango fruit ripening & ripe fruit quality parameters including color, firmness, soluble solids concentrations, total acidity, ascorbic acid, total carotenoids, & aroma volatiles were investigated.
Dang 2008
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The exceptional infrageneric diversity of Aloe, and extensive therapeutic uses in southern Africa, indicate its cultural importance in the subcontinent. These factors highlight the need for the conservation of the species as well as their potential as a source of natural products.
Grace 2008
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The cultural uses, phytochemistry, pharmacological, and toxicological properties of 10 plant species including linden flower and aloe (Aloe vera) was discussed.
Rodriguez-Fragoso 2008
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The article summarizes the active ingredients, anti-inflammatory properties, clinical effects, and therapeutic potential of many agents including aloe vera. Their Potential therapeutic indications include erythema induced by UV light, drug-induced skin eruptions, and psoriasis.
Wu 2008
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Amongst complementary & alternative medicine users in patients with essential hypertension, the most common herbal product used was garlic(69.3%). Others were native herbs (25%), ginger (23.9%), bitter leaf (Vernonia amygdalina) (9.1%), and aloe vera (4.5%). 2.5% used spiritual therapy.
Amira 2007
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Review on the use of traditional medicine by HIV-infected individuals in South Africa in the era of antiretroviral therapy indicates that 14 of the 44 (32%) were currently using traditional medicines, most frequently African potato (9/14) and Aloe vera (3/14).
Babb 2007
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The most frequently used complementary and alternative medicines were herbs (51.9%), faith/prayer healing (49.4%), aloe vera (23.1%), Forever Living Products (16.3%), medicinal tea (14.4%), and Blackstone (12.5%).
Ezeome 2007
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The evidence surrounding the use of aloe-coated gloves in the workplace to prevent dry, sore hands was examined.
Ford 2007
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A non-experimental validation of ethnoveterinary plants and indigenous knowledge used for backyard pigs & chickens revealed that Aloe gel (Aloe vera) is used for internal injuries and the yellow sap from the cut Aloe vera leaf or the juice of Citrus limonia is used to purge the birds.
Lans 2007
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Determination of the medicinal plants used to treat endoparasites and stomach problems in dogs, cats and pigs in British Columbia, Canada indicates that stomach problems were treated with 15 plants including Aloe vera.
Lans 2007a
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A systematic review conducted to determine the efficacy of topical aloe vera for the treatment of burn wounds supports claim that aloe vera might be an effective interventions used in burn wound healing for first to second degree burns.
Maenthaisong 2007
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Among health care professionals who reported herb use, the most common herbs taken were green tea (24%), flax seed (18%), chamomile (11%), and aloe vera (8%).
Gardiner 2006
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Study on the ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada indicates that Aloe vera, Curcuma longa and Ricinus communis are used in both research areas.
Lans 2006
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Review on ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus shows that 21 plants including Aloe vera, Hibsicus sabdariffa, are used for hypertension.
Lans 2006a
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Survey of herbal use by Kansas and Wisconsin Women, Infants, and Children participants indicates that herbs most commonly used by children were aloe vera, chamomile, garlic, peppermint, lavender, cranberry, ginger, echinacea, and lemon.
Lohse 2006
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Hispanics in south Florida reported using herbs and herbal products at a higher rate than that those reported previously for the general population of the United States. Chamomile (58.5%) and aloe vera (45.3%) were used most frequently.
Ortiz 2006
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20 plant extracts have been widely used as topical applications for wound-healing, anti-aging, and disease treatments including ginkgo biloba, echinacea, ginseng, grape seed, green tea, lemon, lavender, rosemary, thuja, sarsaparilla, soy, prickly pear, sagebrush, jojoba and aloe vera.
Hsu 2005
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[Aloe vera gel: update for dentistry.]
Wynn 2005
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Herbal medicine use including echinacea [48%], aloe vera [30%], ginseng [28%], garlic [27%], and ginkgo biloba [22%] were the most common among surgical patients and are consistent with the substantial increase in the use of alternative medical therapies.
Adusumilli 2004
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Review on attitudes and beliefs among Mexican Americans about type 2 diabetes indicates that herbal therapies, such as prickly pear cactus (nopal) and aloe vera (savila) are effective treatments.
Coronado 2004
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Some plants including Ficus bengalensis, Glycyrrhiza glabra, Curcuma longa, Centella asiatica and Aloe vera, have been screened scientifically to evaluate their wound healing activity in different pharmacological models and patients, but the potential of most remains unexplored.
Biswas 2003
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Botanical medicines Centella asiatica and Aloe vera have been used for decades, both topically and internally, to enhance wound repair, and scientific studies are now beginning conducted to validate efficacy and explore mechanisms
MacKay 2003
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Hispanic or non-Hispanic whites aged between 65-74 years revealed that half of them had used herbal medicines like spearmint, chamomile, aloe vera, garlic, brook-mint, osha, lavender, ginger, ginseng, and camphor.
Zeilmann 2003
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77% of population in United States-Mexico border city have been found to use Complementary and alternative medicine. One of the common herbal remedy was aloe vera (8.5%).
Rivera 2002
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Mexican women living in the United States were found to use herbal therapies of traditional Mexican culture, including manzanilla (chamomile), savila (aloe vera), ajo (garlic), una de gato (cat's claw), and yerba buena (spearmint).
Zenk 2001
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Aloe vera, Bryophyllum pinnatum, Citrus sp. and Momordica charantia were
the main medicinal plants being used for poultry health problems in Trinidad
and Tobago
Lans 1998
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100 adults in managed care surveyed about herbal use found that the most
used are aloe vera, honey, peppermint, garlic, eucalyptus, and rose hips
Brown 1991
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Traditional medicinals entering modern health include Ammi visnaga,
Cymbopogon proximus, Nigella sativa, Aloe vera, Urginea maritima,
Phytolacca americana, Euphorbia sp., Glycyrrhiza glabra, Cynara scolymus
and Solanum laciniatum
Sayed 1980
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Monograph in "A Modern Herbal" by Mrs. M. Grieve at
botanical.com
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| Adverse Effects & Toxicity |
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Ingestion of Aloe vera is associated with diarrhea, electrolyte imbalance, kidney dysfunction, and conventional drug interactions; episodes of contact dermatitis, erythema, and phototoxicity have been reported from topical applications.
Boudreau 2006
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[Aloe vera-induced acute toxic hepatitis in a healthy young man.]
Kanat 2006
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Threshold limit value is based on inhalable fraction and is applicable for dusts that are insoluble or poorly soluble & have low toxicity, which may have limited protective ability due to the irritant nature of certain dusts (e.g. aloe vera).
Lacey 2006
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Patch testing of 702 consecutive patients with an oily extract from the leaves, Aloe pulvis from the entire plant and concentrated Aloe vera gel indicates that none of the subjects showed any reaction to these preparations.
Reider 2005
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[Aggravation of preexisting dermatosis with aloe vera.]
Uppal 2003
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39-year-old liver transplant patient who took a laxative containing aloe for ten months, developed melanosis coli. One year after stopping the anthranoid, the pigments disappeared but a polypoid lesion appeared.
Willems 2003
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The FDA?s final ruling states that the stimulant laxative ingredients of aloe (including aloe extract and aloe flower extract) in over-the- counter (OTC) drug products are not generally recognized as safe and effective, or are misbranded.
FDA 2002
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Life-long Aloe vera ingestion does not cause any obvious harmful and deleterious side effects in SPF Fisher rats and could also be beneficial for the prevention of age-related pathology.
Ikeno 2002
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A 47-year-old South African, developed acute oliguric renal failure and liver dysfunction after ingestion of an herbal remedy, found by Mass spectrometric and chromatographic analysis, to contain Cape aloes.
Luyckx
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The anthraquinones aloe-emodin, emodin and rhein were found to be phototoxic in vitro. Probable mechanism may be through the involvement of singlet oxygen and stable photoproducts.
Vargas 2002
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Aloe emodin was found to generate singlet oxygen when irradiated with UV light and this photochemical mechanism is the most likely pathway responsible for the phototoxicity of Aloe emodin.
Vath 2002
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In Ovalbumin sensitized rat models treated intranasally with aloe vera there was differentiation of CD4+ lymphocytes, mediated through regulating the expression of Th1 and Th2 cytokines. Aloe vera treatment may be a selective method to treat allergic rhinitis. [Article in Chinese]
Yu 2002
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Medium Lethal Concentrations (LC50 value) of Aloe vera (L.) obtained from Artemia salina L. the brine shrimp larva, was equivalent to in vivo LD50 value done in mice and this could be an alternative method for predicting acute toxicity of plant extracts.
Logarto Parra 2001
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Popular remedies that can cause dermatological side-effects include St John's Wort, kava, aloe vera, eucalyptus, camphor, henna and yohimbine.
Ernst 2000
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Inhibition of the catalytic activity of topoisomerase II contributes to anthraquinone (emodin, danthron, and aloe-emodin) induced genotoxicity and mutagenicity.
Mueller 1999
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Immunosuppressed mice treated with the whole extract of Aloe vera (L) achieved restoration of immunological parameters in cellular immune response and phagocytosis but not humoral immunity.
Oronzo-Barocio 1999
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Formulations of acemannan as a denture adhesive were evaluated for pH changes and adhesive strength in dry and wet conditions. They had some
cytotoxicity to human gingival fibroblasts
Tello 1998
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Toxic low mol. wt compounds of Aloe vera gel, induced disruption of intercellular junctions of chicken fibroblasts and inhibited the production of reactive oxygen species by human polymorphonuclear leukocytes.
Avila
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Data from animal, human metabolism or kinetic studies, clinical trials and rodent carcinogenicity studies do not support concern that emodin and aloe-emodin poses a genotoxic risk to humans under prescribed use conditions.
Brusick 1997
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Tk-mutations in mouse lymphoma L5178Y cells were induced by emodin,
danthron and aloe-emodin. They also inhibited topoisomerase II-mediated
decatenation
Muller 1996
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Dimethylhydrazine-induced colorectal tumors in male mice were not promoted
by aloin- or sennoside-enriched diets (0.03%)
Siegers 1993
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Acemannan showed no toxicity at 5% of rat diet for 2 weeks or 2 gm/kg to
rats for 6 months or 1.5 gm/kg to dogs for 3 months
Fogelman 1992b
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No significant toxicity were found with acemannan at 80 mg/kg iv or 200
mg/kg ip in mice, 15 mg/kg iv or 50 mg/kg ip in rats, and 10 mg/kg iv or 50
mg/kg ip in dogs. Increased macrophages & monocytes were observed
Fogleman 1992a
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The LD50 values in mice vary from <250 to >1500 mg/kg IP. In rats there was CNS depression. Post mortem findings showed haemorrhagic lesions. Several rats died within 36 hours of injection, but no abortifacient activity was seen.
Parry 1992
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Burning sensation was experienced by 4 adults after application of aloe vera or
vitamin E preparations to skin that had been subjected to a chemical peel or
dermabrasion
Hunter 1991
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Contact dermatitis to Aloe arborescens (No abstract.
Shoji 1982
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A 47 year old man exhibited hypersensitivity after 4 years of oral and topical
aloe
Morrow 1980
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[Acute bullous allergic dermatitis due to local application of aloe leaves]
[Article in Russian] (No abstract)
Savchak 1977
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[Case of an allergic reaction to the administration of aloe juice into the nose] [Article in Russian] (No abstract
Diba 1974
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[Anaphylactic shock after injection of aloe] [Article in Russian] (No abstract)
Trakhtenberg 1970
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Warning it might cause nausea & dermatitis but no references
U Arizona
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| Interactions |
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The effect of Aloe on the human absorption of vitamins C and E, is reported. The plasma bioavailability of vitamins C and E were determined in normal fasting subjects, vitamin C (8 Subjects)and vitamin E (ten subjects). Aloe was found to increase the absorption of both of these vitamins.
Vinson 2005
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A 35-year-old woman lost 5 L of blood during surgery as a result of a possible herb-drug interaction between Aloe vera and sevoflurane.
Lee 2004
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A Review of herbal medication revealed aloe latex to interact with corticosteriods.
Abebe 2003
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Aloin may get metabolized to aloe-emodin (a quinone aglycone) after its ingestion, which may cause acceleration of the ethanol metabolism in rats in vivo.
Chung 1996
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Aloe caused a faster elimination of ethanol from blood of normal rats by preventing the effects of ethanol in decreasing the microsomal enzyme activities relating to its own metabolism
Sakai 1989
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Aloes treatment revealed antimetastatic properties, reduction of tumor mass, metastatic foci and metastasis frequency. It also potentiates the antitumor effect of 5-fluorouracil and cyclophosphamide. [Article in Russian]
Gribel 1986
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| Contraindications |
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| Animal Studies |
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An Evaluation of antioxidant, antinociceptive, and anti-inflammatory activities of ethanol extracts from Aloe saponaria HawIt showed that ethanol extracts of aloe may be useful as a functional food or as a drug against reactive oxygen species mediated diseases.
Yoo 2008
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Study on the effect of Aloe vera leaf pulp extract on Ehrlich ascites tumors in mice shows that A. vera could be proposed as a prophylactic for cancer prevention.
Akev 2007
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The prophylactic effect of the main lectin present in Aloe vera leaf pulp extract (Aloctin I) was assayed against Ehrlich ascites tumors in mice and the results suggest that the tumor preventive effect of Aloctin I could be due to its immunomodulatory activity.
Akev 2007a
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The antitumor-promoting activity of Aloe vera on 2-stage skin carcinogenesis, induced by topical application of 7,12-dimethylbenz(a)anthracene and promoted by treatment of croton oil for 16 weeks in Swiss albino mice was evaluated and its Chemopreventive potential confirmed.
Chaudhary 2007
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A study to evaluate the effect of hydrochloric extract of Tectona grandis on experimentally induced wounds in rats and compare the effects observed with a known wound healing agent, Aloe vera found the leaf extract possesses wound healing activity.
Majumdar 2007
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The effect of an extract from Aloe vera gel containing a high concentration of polyphenols on experimentally induced insulin resistance in mice was investigated which revealed that Aloe vera gel could be effective for the control of insulin resistance.
P?z 2007
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